Objective: To explore in an interdisciplinary way the application of three fire risk reduction measures in the historical center of the city of Trogir: creation of an operational plan for responding and saving cultural heritage in the event of a fire, the ARICA method for calculating the fire risk index of the city core, and a survey of residents related to the construction and household conditions, specific habits and perception of vulnerability in terms of fire protection. Methods: Using the ARICA method, a numerical assessment of fire hazard was calculated for the observed facility. The survey questionnaire collected data on the state of construction and the state of households, specific habits and the perception of residents' vulnerability in terms of fire danger. Results: The ARICA calculation method showed a moderate fire hazard for the observed object (1.193). The survey questionnaire confirmed the construction defects of the observed space. It was shown that the residents are not convinced whether they feel safe from the fire danger and have confidence in the firefighters that they will come in time and put out the fire. Fire is perceived as the main danger, while the element of human carelessness is considered to be the main cause. Conclusions: The operational rescue plan is an effective operational measure to mitigate the risk of fire on cultural heritage and can be used as a model for other cities in the Republic of Croatia. The ARICA method can be successfully applied and can be used to create a fire risk map. Applying the method can compensate for the shortcomings of the legal framework for the assessment of the risk of fire in historic cities. By surveying residents, relevant data can be collected on the construction condition and the condition of households, the respondents' habits regarding fire protection and the perception of danger from fire risk.