Aim: The aim was to investigate the prevalence of primary and secondary Sjögren's syndrome in Dalmatia, clinical features and presence of specific autoantibodies and other serological indicators of Sjögren's syndrome. Methods: We investigated 115 patients treated at Department for clinical immunology and rheumatology in Clinical hospital center Split in a cross-sectional study during 2012. The diagnosis of Sjögren's syndrome was established for all patients according to the classification critera proposed by the American-European Consensus Group. Results: Average age of patients with primary SS is 55 years and average age of patients with secondary is 57 years. The most common symptom is dryness of eyes and mouth, presented in 97% of patients with primary SS and in total number of patients with secondary SS. Articular manifestation has been presented in 38% of patients with primary SS and in 83% of patients with secondary SS. Anti Ro antibodies have been presented in 95% of patients with primary SS and in 97% of patients with secundary SS. Prevalence of anti La antibodies is 61% in primary SS and 51% in secundary SS. Conclusion: Primary SS is more common than secondary SS. There was no deviation from current reports concerning age range. The high female to male predominance of SS is confirmed in both forms. Clinical features of SS in Dalmatia are similar to the reports in the literature with particular characteristics such as less common occurrence of parotid gland enlargement. Our study revealed that the prevalence of specific antibodies, especially anti La antibodies, has shown higher than in the literature. Interestingly, the reduced values of components of the complement C₃ and C₄ occur more frequently than in previous reports. Assocciation with spondyloarthropathia has been observed as a special feature of secondary SS.