Title Patohistološki nalazi uzoraka tkiva jetre u KBC-u Split : retrospektivna četverogodišnja studija Title (english) Pathohistological findings of liver tissue samples at University Hospital of Split: a four-year retrospective study Author Toni Bubić Mentor Sandra Zekić Tomaš (mentor)Committee member Katarina Vilović (predsjednik povjerenstva)Committee member Ivana Mrklić (član povjerenstva)Committee member Zenon Pogorelić (član povjerenstva)Granter University of Split Defense date and country 2020, Croatia Scientific / art field, BIOMEDICINE AND HEALTHCARE Abstract CILJ ISTRAŽIVANJA: Osnovni cilj ovog istraživanja bio je odrediti koje su patohistološke karakteristike uzoraka tkiva jetre u KBC-u Split u vremenskom razdoblju od 01. siječnja 2015. godine do 31. prosinca 2018. godine. Sekundarni cilj bio je odrediti kojim dijagnostičkim postupkom su dobiveni uzorci tkiva jetre i učestalost patohistoloških dijagnoza ovisno o spolu bolesnika.
MATERIJALI I METODE: Podatci su prikupljeni pregledom baze podataka Odjela Patologije, Kliničkog zavoda za Patologiju, Sudsku medicinu i Citologiju KBC-a Split te je zabilježeno 448 patohistoloških nalaza sa šifrom organa jetre. Svi navedeni patohistološki nalazi su uključeni u studiju. Dobiveni su podatci o dobi i spolu bolesnika, godini uzorkovanja, vrsti materijala, uputnoj dijagnozi, patohistološkoj dijagnozi te primarnom sijelu presadnice.
REZULTATI: 448 uzoraka tkiva jetre zaprimljeno je u Odjel Patologije, Kliničkog zavoda za Patologiju, Sudsku medicinu i Citologiju KBC-a Split. 245 (54,7%) bolesnika su bili muškarci. Prosječna dob muških bolesnika je bila 63 godine (8-88), a ženskih 60 godina (1-87). Postupkom biopsije pod kontrolom ultrazvuka dobiveno je 369 (82,41%) uzoraka, dok je preostalih 79 (17,6%) dobiveno operacijskim zahvatom. Najučestalija uputna dijagnoza, pod kojom su uzorci tkiva jetre primljeni na patohistološku analizu, bila je dijagnoza presadnice u jetru u 121 (27%) uzorku. 148 (33%) uzoraka tkiva jetre nije imalo navedenu uputnu dijagnozu. Najučestalija postavljena patohistološka dijagnoza bila je dijagnoza presadnice u jetru u 135 (30,1%) bolesnika. Najučestalija presadnica u jetru bila je podrijetla karcinoma debelog crijeva ili nepoznatog sijela, što je zabilježeno u 36 (26,7%) slučajeva.
ZAKLJUČCI: Biopsija jetre predstavlja zlatni standard u dijagnostici jetrenih presadnica. Obzirom na učestalost i anatomsku povezanost, presadnice karcinoma debelog crijeva najučestalije su sekundarne novotvorine jetre. Bez obzira na dob i spol bolesnika, biopsija pod kontrolom ultrazvuka je češće primjenjivan postupak od operacijskog zahvata za uzorkovanje tkiva jetre. Za dobru patohistološku dijagnozu, suradnja patologa i kliničara od iznimne je važnosti.
Abstract (english) OBJECTIVES: The main aim of this study was to determine pathohistological characteristics of liver tissue samples in University Hospital of Split in the period from January 01st, 2015 till December 31st, 2018. Secondary aim was to determine by which diagnostic procedure liver tissue samples were obtained and incidence of diagnosis depending on the gender of the patients.
MATERIALS AND METHODS: Data were collected by reviewing the database of the Department of Pathology, Clinical Institute of Pathology, Forensic Medicine and Citology of Split, and 448 pathohistological findings were noted with the code of liver organ. All listed pathohistological findings were included in the study. Data on the age and sex of patients, the year of sampling, the type of material, the refferal diagnosis, the pathohistological diagnosis and primary site of the metastases were obtained.
RESULTS: 448 liver tissue samples were received in the Department of Pathology, Clinical Institute of Pathology, Forensic Medicine and Citology at University Hospital of Split. 245 (54.7%) patients were male. The median age for men was 63 (8-88), and for women 60 (1-87). By using ultrasound guided biopsy, 369 (82.41%) liver tissue samples were obtained and the remaining 79 (17.6%) were obtained by surgical procedure. The most common refferal diagnosis, under which liver samples were admitted for pathohistological analysis, was liver metastasis. 121 (27%) samples were adressed as liver metastasis. 148 (33%) liver tissue samples did not have stated refferal diagnosis. During pathohistological analysis, in 135 (30.1%) patients the diagnosis of liver metastasis was made and it was the most common pathohistological diagnosis. The most frequent liver metastasis originated from colorectal carcinoma or the origin was stated as the unknown, which was reported in 36 (26.7%) cases.
CONCLUSION: Liver biopsy is the gold standard for diagnosing liver metastases. Considering incidence and anatomical connection, metastases of colorectal carcinoma are the most common secondary liver neoplasms. Without the consideration of the patients age nor gender, ultrasound guided liver biopsy was more often in use for sampling liver tissue than surgical procedure. To make a good pathohistological diagnosis, it is important to establish a good communication between pathologist and clinician.
Keywords
Bolesti jetre
Biopsija
Metastaze novotvorina
Keywords (english)
Liver Diseases
Biopsy
Neoplasm Metastasis
Language croatian URN:NBN urn:nbn:hr:171:987682 Study programme Title: Medicine Type of resource Text File origin Born digital Access conditions Open access Terms of use Repository MEFST Repository Created on 2020-12-15 11:29:29
