prikaz prve stranice dokumenta A comparative cross-sectional study for understanding the difference in prevalence of skin changes in patients with primary and secondary Sjögren’s syndrome
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master's thesis
A comparative cross-sectional study for understanding the difference in prevalence of skin changes in patients with primary and secondary Sjögren’s syndrome
Split: University of Split, School of Medicine, 2024. urn:nbn:hr:171:420124
Berg, Emilie
University of Split
School of Medicine

Cite this document

Berg, E. (2024). A comparative cross-sectional study for understanding the difference in prevalence of skin changes in patients with primary and secondary Sjögren’s syndrome (Master's thesis). Split: University of Split, School of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:171:420124

Berg, Emilie. "A comparative cross-sectional study for understanding the difference in prevalence of skin changes in patients with primary and secondary Sjögren’s syndrome." Master's thesis, University of Split, School of Medicine, 2024. https://urn.nsk.hr/urn:nbn:hr:171:420124

Berg, Emilie. "A comparative cross-sectional study for understanding the difference in prevalence of skin changes in patients with primary and secondary Sjögren’s syndrome." Master's thesis, University of Split, School of Medicine, 2024. https://urn.nsk.hr/urn:nbn:hr:171:420124

Berg, E. (2024). 'A comparative cross-sectional study for understanding the difference in prevalence of skin changes in patients with primary and secondary Sjögren’s syndrome', Master's thesis, University of Split, School of Medicine, accessed 11 March 2025, https://urn.nsk.hr/urn:nbn:hr:171:420124

Berg E. A comparative cross-sectional study for understanding the difference in prevalence of skin changes in patients with primary and secondary Sjögren’s syndrome [Master's thesis]. Split: University of Split, School of Medicine; 2024 [cited 2025 March 11] Available at: https://urn.nsk.hr/urn:nbn:hr:171:420124

E. Berg, "A comparative cross-sectional study for understanding the difference in prevalence of skin changes in patients with primary and secondary Sjögren’s syndrome", Master's thesis, University of Split, School of Medicine, Split, 2024. Available at: https://urn.nsk.hr/urn:nbn:hr:171:420124

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Metadata
TitleA comparative cross-sectional study for understanding the difference in prevalence of skin changes in patients with primary and secondary Sjögren’s syndrome
Title (croatian)Usporedna presječna studija za razumijevanje razlike u prevalenciji promjena na koži kod pacijenata s primarnim i sekundarnim Sjögrenovim sindromom
AuthorEmilie Berg
MentorDaniela Marasović Krstulović (mentor)
Committee memberNeira Puizina Ivić (predsjednik povjerenstva)
Committee memberMislav Radić (član povjerenstva)
Committee memberAntoanela Čarija (član povjerenstva)
GranterUniversity of Split
School of Medicine
Split
Defense date and country2024-07-05, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract
Background: Skin changes are among the most common manifestations of Sjögren´s syndrome (SS). While being reported in literature, there is a substantial gap in existing literature regarding skin manifestations, as they are often overshadowed by sicca symptoms. Objectives: Explore the difference in skin changes between primary SS (pSS) and secondary SS (sSS), as well as the association between skin changes and organ involvement and disease duration. Additionally, an assessment of... More distribution and severity of skin manifestations. Materials and methods: Observational cross-sectional study included patients aged 18 years or older with diagnosis of pSS or sSS. Clinical data was collected from patient papers and digital medical records from clinical department, daily hospital and outpatient clinic of Department of Rheumatology and Clinical Immunology, Internal Clinic, University Hospital of Split, Croatia. Experimental group and control included 117 and 200 patients, respectively. For the analysis of difference in skin changes between pSS and sSS group, and association between skin changes and organ involvement and disease duration, Chi-square test of Independence was used. Results: Among the 317 study participants there was reported a total of 113 patients that exhibited skin changes. Most of the patients had a single type of skin manifestations, while 31 patients had two or more different skin changes. The most frequent skin changes in pSS patients were Raynaud phenomenon, rash and alopecia, while the most frequent manifestations in sSS were erythema, discoid lupus and Raynaud phenomenon. We noted a statistically significant difference in skin changes in pSS and sSS (30% vs 45%, p = 0.006). The relationship between the existence of organ involvement and skin changes was not statistically significant (p = 0.511). Similarly, we were not able to prove a statistically significant association between disease duration and manifestation of skin changes in patients with SS (p = 0.773). Conclusion: Our study revealed that skin changes are more frequent in patients with sSS compared to pSS. A wide spectrum of skin changes was observed. The most frequent cutaneous disorder in pSS was Raynaud phenomenon, while in sSS the most frequent was erythema. Regarding the association between skin changes and disease duration or organ involvement, we were not able to find an association that was statistically significant for either of the factors. Less
Abstract (croatian)
Pozadina: Kožne manifestacije su među najčešćim manifestacijama Sjögrenova sindroma (SS). Iako se o njima izvještava u literaturi, postoji značajan nedostatak u istraživanju i postojećoj literaturi u vezi s dermatološkim manifestacijama, budući da su one često zasjenjene sicca simptomima. Ciljevi: Istražiti razliku u pojavnosti kožnih promjena između primarnog SS (pSS) i sekundarnog SS (sSS), kao i povezanost između kožnih promjena i zahvaćenosti organa i trajanja bolesti.... More Dodatni cilj bio je procjeniti distribuciju i ozbiljnost kožnih manifestacija. Materijali i metode: Opservacijska presječna studija. Uključeni su bolesnici stariji od 18 godina s dijagnosticiranim pSS-om ili sSS-om. Klinički podaci prikupljeni su iz povijesti bolesti i digitalnih medicinskih zapisa iz odjela, dnevne bolnice i poliklinike Zavoda za reumatologiju i kliničku imunologiju, Klinike za unutarnje bolesti, KBC Split, Hrvatska. Pokusnu skupinu činilo je 117, a kontrolnu 200 bolesnika. Za analizu razlika u kožnim promjenama između pSS i sSS skupine te povezanosti kožnih promjena i zahvaćenosti organa i trajanja bolesti, korišten je Chi-kvadrat test neovisnosti. Rezultati: Među 317 sudionika istraživanja utvrđeno je je ukupno 113 pacijenata koji su imali kožne promjene. Većina bolesnika imala je jednu vrstu kožnih manifestacija, dok je 31 bolesnik imao dvije ili više različitih kožnih promjena. Najčešće kožne promjene u bolesnika s pSS-om bile su Raynaudov fenomen, osip i alopecija, dok su najčešće manifestacije sSS-a bile eritem, diskoidni lupus i Raynaudov fenomen. Primijetili smo statistički značajnu razliku u pojavnosti kožnih promjenama između pSS i sSS (30 % vs. 45 %, p=0,006). Nije utvrđena povezanost između zahvaćenosti unutarnjih organa i promjena na koži (p = 0,511). Slično tome, nismo uspjeli utvrditi povezanost između trajanja SS bolesti i pojave kožnih promjena (p = 0,773). Zaključci: Naše je istraživanje pokazalo da su kožne promjene češće kod pacijenata sa sSSom u odnosu na pSS. Uočen je širok spektar kožnih promjena. Najčešći kožni poremećaj u pSSu bio je Raynaudov fenomen, dok je u sSS-u najčešći eritem. Što se tiče povezanosti između promjena na koži i trajanja bolesti ili zahvaćenosti organa, nismo uspjeli pronaći povezanost koja je statistički značajna ni za jedan od čimbenika. Less
Keywords
Keywords (croatian)
Languageenglish
URN:NBNurn:nbn:hr:171:420124
Study programmeTitle: Medical Studies in English
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Embargo expiration date: 2024-07-05
Terms of useLicence In copyright icon
RepositoryMEFST Repository
Created on2024-07-04 13:28:29
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