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master's thesis
KLINIČKE OSOBITOSTI CROHNOVE BOLESTI U BOLESNIKA S IZVANCRIJEVNIM MANIFESTACIJAMA BOLESTI
Split: University of Split, School of Medicine, 2018. urn:nbn:hr:171:519332
Pavić, Berna
University of Split
School of Medicine
Internal medicine

Cite this document

Pavić, B. (2018). KLINIČKE OSOBITOSTI CROHNOVE BOLESTI U BOLESNIKA S IZVANCRIJEVNIM MANIFESTACIJAMA BOLESTI (Master's thesis). Retrieved from https://urn.nsk.hr/urn:nbn:hr:171:519332

Pavić, Berna. "KLINIČKE OSOBITOSTI CROHNOVE BOLESTI U BOLESNIKA S IZVANCRIJEVNIM MANIFESTACIJAMA BOLESTI." Master's thesis, University of Split, School of Medicine, 2018. https://urn.nsk.hr/urn:nbn:hr:171:519332

Pavić, Berna. "KLINIČKE OSOBITOSTI CROHNOVE BOLESTI U BOLESNIKA S IZVANCRIJEVNIM MANIFESTACIJAMA BOLESTI." Master's thesis, University of Split, School of Medicine, 2018. https://urn.nsk.hr/urn:nbn:hr:171:519332

Pavić, B. (2018). 'KLINIČKE OSOBITOSTI CROHNOVE BOLESTI U BOLESNIKA S IZVANCRIJEVNIM MANIFESTACIJAMA BOLESTI', Master's thesis, University of Split, School of Medicine, accessed 26 May 2022, https://urn.nsk.hr/urn:nbn:hr:171:519332

Pavić B. KLINIČKE OSOBITOSTI CROHNOVE BOLESTI U BOLESNIKA S IZVANCRIJEVNIM MANIFESTACIJAMA BOLESTI [Master's thesis]. Split: University of Split, School of Medicine; 2018 [cited 2022 May 26] Available at: https://urn.nsk.hr/urn:nbn:hr:171:519332

B. Pavić, "KLINIČKE OSOBITOSTI CROHNOVE BOLESTI U BOLESNIKA S IZVANCRIJEVNIM MANIFESTACIJAMA BOLESTI", Master's thesis, University of Split, School of Medicine, Split, 2018. Available at: https://urn.nsk.hr/urn:nbn:hr:171:519332

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Metadata
TitleKLINIČKE OSOBITOSTI CROHNOVE BOLESTI U BOLESNIKA S IZVANCRIJEVNIM MANIFESTACIJAMA BOLESTI
Title (english)CLINICAL CHARACTERISTICS OF CROHN'S DISEASE IN PATIENTS WITH EXTRAINTESTINAL MANIFESTATIONS
AuthorBerna Pavić
MentorAndre Bratanić (mentor)
Committee memberŽeljko Puljiz (predsjednik povjerenstva)
Committee memberJoško Božić (član povjerenstva)
Committee memberDamir Bonacin (član povjerenstva)
GranterUniversity of Split
School of Medicine
(Internal medicine)
Split
Defense date and country2018, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract
Cilj istraživanja: Cilj ovog istraživanja bio je utvrditi učestalost i tip ekstraintestinalih manifestacija u pacijenata oboljelih od Crohnove bolesti u Splitsko-dalmatinskoj županiji u razdoblju od 2006.-2014. godine te analizirati njihovu povezanost s određenim karakteristikama samih pacijenata i njihove osnovne bolesti. Materijali i metode: U istraživanje je uključeno 216 ispitanika iz Registra za upalne bolesti crijeva Kliničkog Odjela za gastroenterologiju i hepatologiju KBC Split od 2006. do 2014. godine. Provedeno istraživanje je bilo presječno retrospektivno epidemiološko. Za obradu podataka korišten je SPSS program. Rezultati: Analizirano je ukupno 216 pacijenata, od kojih 121 muškarac (56%) i 95 žena (44%). Od 216 pacijenata s dijagnozom Crohnove bolesti,njih 37 je imali EIM. U skupini ispitanika s EIM medijan dobi početka bolesti za 5 godina je manji nego u skupini bez komplikacija (p=0,05). Također, u skupini bolesnika s EIM je 1,5 puta više žena nego u skupini ispitanika bez EIM (p=0,023). Izgled za pojavnost EIM za 2,4 puta je veći kod žena nego kod muškaraca (p=00,016). Udio ispitanika s lokalizacijom u debelom crijevu je za 1,8 puta veći u skupini s EIM (p=0,016) dok je izgled za pojavnost EIM za 2,7 puta veća kod lokalizacije bolesti u debelom crijevu u odnosu na ostale lokalizacije (p=0,007).U skupini bolesnika s EIM češće su korišteni imunosupresivi (68%) I anti TNF terapija (35%). Zaključak: Analiza epidemioloških i kliničkih karakteristika pacijenata s Crohnovom bolesti i njenih EIM bi mogla bitno utjecati na usavršavanje terapijskog pristupa a time i na poboljšanje kvalitete života pacijenata.
Abstract (english)
Materials and methods: The sample of patients includes all patients with Crohn's disease registered in the inflammatory bowel register of the department of Gastroenterology and Hepatology of University of Split from 2006. till 2014. The conducted study was retrospective. SPSS software was used for data analysis. Results: Overall 216 patients were analyzed, from which 121 men (56%) and 95 women (44%). From the 216 patients, 37 had EIM. In the group of patients with EIM the median of age of onset was 5 years lower than in the group without EIM (p=0,05). Also, in the group with EIM there was 1,5 times more women than in the group without EIM (p=0,023). The odds for EIM is 2,4 times higher in women than in men. The number of patients with colonic localization is 1,8 times higher in the group with EIM, while the odds for manifestation of EIM is 2,7 times greater in patients with colonic disease in comparisson with other localizations. In the group with EIM immunosuppressants (68%) and anti TNF therapy (35%) were used more often. Conclusion: Analysis of epidemiological and clinical characteristics of patients with Crohn's disease and its' EIM could greatly improve our therapeutical approach as well as our patients' life quality.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:171:519332
Study programmeTitle: Medicine
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
RepositoryMEFST Repository
Created on2018-11-12 08:29:04