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master's thesis
EVALUATION OF STRESS RESPONSE IN PATIENTS FOLLOWING CARDIAC SURGERY
Split: University of Split, School of Medicine, 2020. urn:nbn:hr:171:550610
Vötgen, Lara-Sophia
University of Split
School of Medicine
Anesthesiology and intensive medicine

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Vötgen, L. S. (2020). EVALUATION OF STRESS RESPONSE IN PATIENTS FOLLOWING CARDIAC SURGERY (Master's thesis). Retrieved from https://urn.nsk.hr/urn:nbn:hr:171:550610

Vötgen, Lara Sophia. "EVALUATION OF STRESS RESPONSE IN PATIENTS FOLLOWING CARDIAC SURGERY." Master's thesis, University of Split, School of Medicine, 2020. https://urn.nsk.hr/urn:nbn:hr:171:550610

Vötgen, Lara Sophia. "EVALUATION OF STRESS RESPONSE IN PATIENTS FOLLOWING CARDIAC SURGERY." Master's thesis, University of Split, School of Medicine, 2020. https://urn.nsk.hr/urn:nbn:hr:171:550610

Vötgen, L. S. (2020). 'EVALUATION OF STRESS RESPONSE IN PATIENTS FOLLOWING CARDIAC SURGERY', Master's thesis, University of Split, School of Medicine, accessed 17 May 2022, https://urn.nsk.hr/urn:nbn:hr:171:550610

Vötgen LS. EVALUATION OF STRESS RESPONSE IN PATIENTS FOLLOWING CARDIAC SURGERY [Master's thesis]. Split: University of Split, School of Medicine; 2020 [cited 2022 May 17] Available at: https://urn.nsk.hr/urn:nbn:hr:171:550610

L. S. Vötgen, "EVALUATION OF STRESS RESPONSE IN PATIENTS FOLLOWING CARDIAC SURGERY", Master's thesis, University of Split, School of Medicine, Split, 2020. Available at: https://urn.nsk.hr/urn:nbn:hr:171:550610

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Metadata
TitleEVALUATION OF STRESS RESPONSE IN PATIENTS FOLLOWING CARDIAC SURGERY
Title (croatian)PROCJENA STRESNOG ODGOVORA KOD BOLESNIKA NAKON KARDIOKIRURŠKOG ZAHVATA
AuthorLara-Sophia Vötgen
MentorSandro Glumac (mentor)
Committee memberJoško Božić (predsjednik povjerenstva)
Committee memberIvana Mudnić (član povjerenstva)
Committee memberIvana Pavlinac Dodig (član povjerenstva)
GranterUniversity of Split
School of Medicine
(Anesthesiology and intensive medicine)
Split
Defense date and country2020-07-23, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Anesthesiology and Reanimatology
Abstract
Objectives: The aim of the current study was to investigate the magnitude of stress response in patients undergoing cardiac surgery, with an additional focus on the possible variations of stress response between cardiac surgery with and without CPB. Patients and methods: This study enrolled 125 patients, aged between 41 and 84 years, who were scheduled for elective CABG, heart valve surgery or combined surgery, with or without CPB. Excluded from the study were patients with mental illness; adrenal gland disease; requiring steroid treatment for longer than 7 days in the past year; alcohol (> 20 g per day or > 150 g per week) or controlled substance abuse; and additionally, corticosteroid treatment throughout the study period. Patient serum cortisol levels were determined 1 day before surgery (at 08:00) and on the 1st (at 08:00, 16:00 and 24:00), 3rd (at 08:00), and 5th (at 08:00) postoperative days. Results: Postoperative cortisol levels were markedly beyond normal range in all measurements. However, a significant difference in the postoperative cortisol levels between cardiac surgery with and without CPB was not observed. Significant positive correlation was found between old age and cortisol levels on the 1st (at 24:00; Pearson correlation coefficient = 0.208, P = 0.023) and 5th (Pearson correlation coefficient = 0.183, P = 0.045) postoperative days. Conclusion: Cardiac surgery induced a significant cortisol response with completely disrupted circadian rhythm in patients. The use of CPB during cardiac surgery had no effect on the level of cortisol response. Old age was associated with a more severe degree of the surgical stress response
Abstract (croatian)
Ciljevi: Cilj istraživanja je bio ispitati stupanj stresnog odgovora kod bolesnika nakon kardiokirurškog zahvata, s dodatnim osvrtom na moguće razlike u stupnju stresnog odgovora ovisno u uporabi izvantjelesnog krvotoka tijekom zahvata. Ispitanici i postupci: Istraživanje je uključilo 125 bolesnika, dobi između 41 i 84 godine, predviđenih za elektivni zahvat aortokoronarnog premoštenja, operacije srčanih zalistaka i kombinirane operacije s ili bez uporabe izvantjelesnog krvotoka. Bolesnici nisu bili uključeni u istraživanje ukoliko su bolovali od psihijatrijske bolesti; bolesti nadbubrežne žlijezde, alkoholne (> 20 g dnevno ili > 150 g tjedno) ili druge ovisnosti; te ukoliko su bili pod kortikosteroidnom terapijom dulje od sedam dana u posljednjih godinu dana. Također bolesnici su se isključili iz istraživanja ukoliko su liječeni kortikosteroidima tijekom trajanja studije. Vrijednost kortizola kod svih bolesnika određena je jutro pred operaciju (u 8:00 sati), prvi poslijeoperacijski dan u tri vremenske točke (u 8:00, 16:00 i 24:00 sata), treće i peto poslijeoperacijsko jutro (u 8:00 sati). Rezultati: Poslijeoperacijske vrijednosti kortizola u svim mjerenjima značajno su povišene u usporedbi s referentnim vrijednostima. Nije uočena značajna razlika poslijeoperacijskih vrijednosti kortizola između kardiokirurškog zahvata s ili bez uporabe izvantjelesnog krvotoka. Utvrđena je značajno pozitivna korelacija između starije dobi i vrijednosti kortizola prvi poslijeoperacijski dan (u 24:00 sata, Pearson koeficijent korelacije = 0.208, P = 0.023) i peto poslijeoperacijsko jutro (Pearson koeficijent korelacije = 0.183, P = 0.045). Zaključak: Kardiokirurški zahvat je uzrokovao značajan stresan odgovor organizma i u potpunosti poremetio cirkadijalni ritam kortizola kod bolesnika. Uporaba izvantjelesnog krvotoka nije pokazala značajan utjecaj na poslijeoperacijske vrijednosti kortizola. Starija dob je bila značajno povezana s izraženijim stupnjem stresnog odgovora izazvanog kardiokirurškim zahvatom
Keywords
Keywords (croatian)
Languageenglish
URN:NBNurn:nbn:hr:171:550610
Study programmeTitle: Medical Studies in English
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
RepositoryMEFST Repository
Created on2020-09-02 07:45:45