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undergraduate thesis
Primjena stichodactyla toksina u liječenju autoimunih bolesti
Split: University of Split, 2018. urn:nbn:hr:226:295730
Bovan, Srećko
University of Split
University Department of Marine Studies

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Bovan, S. (2018). Primjena stichodactyla toksina u liječenju autoimunih bolesti (Undergraduate thesis). Split: University of Split. Retrieved from https://urn.nsk.hr/urn:nbn:hr:226:295730

Bovan, Srećko. "Primjena stichodactyla toksina u liječenju autoimunih bolesti." Undergraduate thesis, University of Split, 2018. https://urn.nsk.hr/urn:nbn:hr:226:295730

Bovan, Srećko. "Primjena stichodactyla toksina u liječenju autoimunih bolesti." Undergraduate thesis, University of Split, 2018. https://urn.nsk.hr/urn:nbn:hr:226:295730

Bovan, S. (2018). 'Primjena stichodactyla toksina u liječenju autoimunih bolesti', Undergraduate thesis, University of Split, accessed 18 April 2024, https://urn.nsk.hr/urn:nbn:hr:226:295730

Bovan S. Primjena stichodactyla toksina u liječenju autoimunih bolesti [Undergraduate thesis]. Split: University of Split; 2018 [cited 2024 April 18] Available at: https://urn.nsk.hr/urn:nbn:hr:226:295730

S. Bovan, "Primjena stichodactyla toksina u liječenju autoimunih bolesti", Undergraduate thesis, University of Split, Split, 2018. Available at: https://urn.nsk.hr/urn:nbn:hr:226:295730

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Metadata
TitlePrimjena stichodactyla toksina u liječenju autoimunih bolesti
Title (english)Application of stichodactyla toxin in the treatment of autoimmune diseases
AuthorSrećko Bovan
MentorMaja Pavela Vrančić (mentor)
Committee memberZvjezdana Popović Perković (predsjednik povjerenstva)
Committee memberMaja Pavela Vrančić (član povjerenstva)
Committee memberFrane Škeljo (član povjerenstva)
GranterUniversity of Split
(University Department of Marine Studies)
Split
Defense date and country2018-09-21, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Biology
Abstract
Stichodactyla helianthus (Ellis, 1768) je vrsta vlasulje prisutna u Karipskom moru. Sadrži neurotoksine koji prvenstveno služe za obranu od predatora. Proučavanje peptida ShK iz ove vrste pokazalo je da osim toksičnog učinka postoji i moguća terapeutska primjena. Stichodactyla toksin ShK djeluje tako da blokira Kv1.3 kanale i zbog toga može suzbiti imunološke odgovore bitne za patogenezu brojnih bolesti kao što su multipla skleroza, psorijaza, reumatoidni artritis, itd. Napravljeno je mnogo sintetičkih analoga ovoga spoja od kojih su najbitniji ShK-Dap22, ShK-F6CA, D-allo-ShK, ShK-170, ShK-192 te ShK-186 koji je pod nazivom dalazatid ušao u kliničko ispitivanje za liječenje plak psorijaze.
Abstract (english)
Stichodactyla helianthus (Ellis, 1768) is a species of anemone present in the Caribbean Sea. It contains neurotoxins that are primarily used as a defense against predators. Investigation of the ShK peptide, derived from this species, showed that besides the toxic effect there is also a possible therapeutic application. Stichodactyla toxin ShK works by blocking Kv1.3 channels and therefore can suppress the immune responses essential for the pathogenesis of numerous diseases such as multiple sclerosis, psoriasis, rheumatoid arthritis, etc. Many synthetic analogues of this compound have been made, the most important of which are ShK-Dap22, ShK-F6CA, D-allo-ShK, ShK-170, ShK-192, and ShK-186 now called dalazatide, which has entered clinical trials for treating plaque psoriasis.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:226:295730
Study programmeTitle: Marine Biology and Ecology
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) biologije i ekologije mora (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) biologije i ekologije mora)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
RepositoryRepository of University Department of Marine Studies
Created on2021-04-21 14:50:33