INTRODUCTION: Autoimmune diseases are chronic diseases marked by a wide spectrum of clinical manifestations. As a result, they have numerous damages in reducing the individual's ability in performing of everyday activities.Precisely because of the chronic course and often the irreversible damage, these diseases directly affect the quality of life of the patients. OBJECTIVE: The purpose of this study was to assess the quality of life of patients suffering from RA, SLE and SS, then examine the differences between certain groups, as well as the HRQOL relationship given the duration of the disease, age and socio-economic factors. SUBJECTS AND METHODS: The study included 94 patients (RA 32, SLE 32, SS 30) who meet ACR criteria for RA, SLICC criteria for SLE and SICCA criteria for SS. The quality of life was examined by using the SF-36 questionnaire which was supplemented by data on the type of disease, gender, the duration of the disease and socio-economic data. RESULTS: Patients with RA have a significantly lower quality of life in the domain of physical functioning and physical pain according to the SF-36 questionnaire in relation to SLE patients (p = 0.005, p = 0.036) while no significant difference has been established compared to SS. In patients with SLE, a significant age-related association with the quality of life in every domain of SF-36 questionnaire was established while the duration of the disease was considerably associated with physical functioning (p = 0.048), vitality and energy (p = 0.038) and with social functioning (p = 0.008). The duration of the disease is not associated with the quality of life in patients with RA and SS. The patients’ age is negatively related to the perception of general health (p = 0.015) in SS.The quality of life in the domain of physical functioning is better in patients with higher education (p = 0.042). The highest values in HRQOL were expressed by singles while the lowest values were expressed by widowers / widows. No connection between thetotal monthly income and employment status with the quality of life is confirmed. CONCLUSION: Our research confirms that patients with RA have poorer HRQOL in relation to patients with SLE and SS. Elderly patients have poorer HRQOL in SS and SLE. The duration of the disease has a negative impact on the quality of life in SLE. In all three groups a connection with marital status was confirmed, where the worst quality of life has been shown with widows / widowers, and the best in patients who live alone.It has also been established that the quality of life is better in patients with a higher level of education. The total monthly income and employment status did not affect the quality of life. A routine assessment of HRQOL is recommended for detecting and monitoring the impact of disease on various aspects of life.